anti-CD52 monoclonal antibody ALLO-647

{
  "id": "MLC-T-ONC-010421",
  "term": "anti-CD52 monoclonal antibody ALLO-647",
  "field": "Oncology and biomedicine",
  "definition": "A monoclonal antibody directed against the cell surface glycoprotein CD52 (CAMPATH-1 antigen; Cambridge pathology 1 antigen), with potential immunodepleting activity. Upon administration, anti-CD52 monoclonal antibody ALLO-647 selectively targets and binds to CD52, thereby triggering a host immune response that results in the lysis of CD52-positive lymphocytes. This leads to immunodepletion and may prevent graft-versus-host disease (GvHD). CD52 is a glycoprotein expressed on the surface of many immune cells, including essentially all B and T lymphocytes.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd52-monoclonal-antibody-allo-647/"
}