anti-minor histocompatibility complex donor T lymphocytes

{
  "id": "MLC-T-ONC-010897",
  "term": "anti-minor histocompatibility complex donor T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of allogeneic, donor-derived T lymphocytes that are specific for a unique set of minor histocompatibility complex antigens (MiHA) exclusively found on the surface of malignant cells, with potential immunomodulating and antineoplastic activities. T lymphocytes are derived from an allogeneic hematopoietic cell transplant (AHCT) donor. Ex vivo, these T cells are exposed to and primed against a select set of host-specific hematopoietic tissue-restricted MiHAs that are expressed on leukemic cells. Then the cells are subsequently expanded. After AHCT and infusion of the anti-MiHA T lymphocytes, these cells target and bind to MiHA antigens expressed on the host's leukemia cells, thereby killing these cancer cells. MiHA are small, cell-surface peptides that are associated with graft-versus-host disease (GvHD). The selected set of MiHAs is expressed mainly, or only, by hematopoietic cells, and overexpressed on leukemic cells.",
  "synonyms": [
    "anti-MiHA T cells",
    "GLIDE",
    "GLIDE cells",
    "MiHA T lympocytes",
    "guided lymphocyte immunopeptide-derived expansion cells",
    "GLIDE T lymphocytes",
    "MiHA-specific T cells",
    "guided lymphocyte immunopeptide derived expansion against MiHAs cells",
    "anti-MiHA donor T lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-minor-histocompatibility-complex-donor-t-lymphocytes/"
}