donor-derived haploidentical IL-21-expanded natural killer cells

{
  "id": "MLC-T-ONC-013145",
  "term": "donor-derived haploidentical IL-21-expanded natural killer cells",
  "field": "Oncology and biomedicine",
  "definition": "A population of ex-vivo human interleukin-21 (IL-21) expanded donor-derived human leukocyte antigen (HLA) haploidentical natural killer (haploNK) cells, with potential immunomodulating and antineoplastic activities. Upon administration in patients undergoing HLA-haploidentical hematopoietic cell transplantation, the donor-derived haploidentical IL-21-expanded NK cells target, lyse and destroy tumor cells. IL-21 promotes sustained ex vivo proliferation of human NK cells and enhances its cytotoxic activity.",
  "synonyms": [
    "allogeneic IL-21-expanded haploNKs",
    "donor-derived haploidentical IL-21-expanded NKs",
    "donor-derived IL-21 expanded NK cells",
    "IL-21-treated HLA-haploidentical donor NK cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/donor-derived-haploidentical-il-21-expanded-natural-killer-cells/"
}