denenicokin

{
  "id": "MLC-T-ONC-012973",
  "term": "denenicokin",
  "field": "Oncology and biomedicine",
  "definition": "A recombinant peptide similar to or identical to endogenous human cytokine interleukin-21 (IL-21) with potential antineoplastic activity. Denenicokin binds to and activates IL-21 receptors, expressed on T-cells, B-cells, dendritic cells (DC), and natural killer (NK) cells, modulating the proliferation and/or differentiation of T and B cells, promoting T cell survival, and increasing the cytolytic activity of cytotoxic T lymphocytes (CTLs) and NK cells.",
  "abbreviation": "rhIL-21",
  "synonyms": [
    "recombinant human interleukin-21"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/denenicokin/"
}