anti-MUC16/CD28 bispecific antibody REGN5668

{
  "id": "MLC-T-ONC-010904",
  "term": "anti-MUC16/CD28 bispecific antibody REGN5668",
  "field": "Oncology and biomedicine",
  "definition": "A bispecific monoclonal antibody against both the tumor-associated antigen (TAA) human mucin 16 (MUC16, cancer antigen 125; CA125; FLJ14303) and the co-stimulatory T-cell-specific surface glycoprotein CD28, with potential antineoplastic and immunostimulating activities. Upon administration, anti-MUC16/CD28 bispecific antibody REGN5668 binds to both CD28 on T cells and MUC16-expressing tumor cells, which cross-links the T cells to the tumor cells. This may result in a potent cytotoxic T-lymphocyte (CTL) response against the MUC16-expressing tumor cells. MUC16, a member of the mucin family of glycoproteins, is overexpressed by several epithelial cancers, including ovarian cancer.",
  "synonyms": [
    "anti-MUC16 x anti-CD28 bispecific antibody REGN5668",
    "MUC16xCD28 bispecific antibody REGN5668"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-muc16-cd28-bispecific-antibody-regn5668/"
}