anti-ROR1/anti-CD3/anti-HSA trispecific antibody NM32-2668

{
  "id": "MLC-T-ONC-011074",
  "term": "anti-ROR1/anti-CD3/anti-HSA trispecific antibody NM32-2668",
  "field": "Oncology and biomedicine",
  "definition": "A trispecific antibody directed against the tumor-associated antigen (TAA) receptor tyrosine kinase-like orphan receptor 1 (ROR1), the T-cell surface antigen CD3 and human serum albumin (HSA), with potential immunostimulating and antineoplastic activities. Upon administration, anti-ROR1/anti-CD3/anti-HSA trispecific antibody NM32-2668 binds to both ROR1 expressed on tumor cells and CD3 expressed on cytotoxic T lymphocytes (CTLs). This activates and redirects CTLs to ROR1-expressing tumor cells, which results in the CTL-mediated death of ROR1-expressing tumor cells. Anti-ROR1/anti-CD3/anti-HSA trispecific antibody NM32-2668 also binds to HSA, which prolongs the half-life of the agent. ROR1, also known as neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), is expressed during embryogenesis and in many types of hematological malignancies. It plays key roles in tumor cell proliferation and survival.",
  "synonyms": [
    "anti-ROR1/CD3/HSA trispecific antibody NM32-2668",
    "ROR1 x CD3 x HSA T-cell engager NM32-2668",
    "ROR1 x CD3 x HSA TCE NM32-2668",
    "ROR1 x CD3 x HSA trispecific antibody NM32-2668",
    "ROR1-targeting TCE NM32-2668"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-ror1-anti-cd3-anti-hsa-trispecific-antibody-nm32-2668/"
}