autologous anti-ROR1 CAR-T cells BMS-986403

{
  "id": "MLC-T-ONC-011498",
  "term": "autologous anti-ROR1 CAR-T cells BMS-986403",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) receptor tyrosine kinase-like orphan receptor 1 (ROR1), with potential immunomodulatory and antineoplastic activities. After isolation, transduction, expansion and reintroduction into the patient, the autologous anti-ROR1 CAR-T cells BMS-986403 are directed to, bind to, and induce selective toxicity in tumor cells expressing ROR1. ROR1, also known as neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), is expressed during embryogenesis and in various hematological and solid malignancies. It plays key roles in tumor cell proliferation and survival.",
  "synonyms": [
    "autologous ROR1-targeted CAR T cells BMS-986403"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-ror1-car-t-cells-bms-986403/"
}