anti-ROR1/CD3 T-cell-engager NVG-111

{
  "id": "MLC-T-ONC-011075",
  "term": "anti-ROR1/CD3 T-cell-engager NVG-111",
  "field": "Oncology and biomedicine",
  "definition": "A bispecific antibody and T-cell engager directed against the tumor-associated antigen (TAA) receptor tyrosine kinase-like orphan receptor 1 (ROR1) and the CD3 antigen found on T lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration, anti-ROR1/CD3 T-cell engager NVG-111 binds to both CD3 on cytotoxic T lymphocytes (CTLs) and ROR1 found on ROR1-expressing tumor cells. This activates and redirects CTLs to ROR1-expressing tumor cells, which results in the CTL-mediated death of ROR1-expressing tumor cells. ROR1, also known as neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), is expressed during embryogenesis and in many types of hematological malignancies. It plays key roles in tumor cell proliferation and survival.",
  "synonyms": [
    "anti-ROR1/CD3 bispecific antibody NVG-111"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-ror1-cd3-t-cell-engager-nvg-111/"
}