anti-ROR1/anti-CD3 bispecific antibody EMB-07

{
  "id": "MLC-T-ONC-011073",
  "term": "anti-ROR1/anti-CD3 bispecific antibody EMB-07",
  "field": "Oncology and biomedicine",
  "definition": "A bispecific antibody directed against both the tumor-associated antigen (TAA) receptor tyrosine kinase-like orphan receptor 1 (ROR1) and the T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon administration, anti-ROR1/anti-CD3 bispecific antibody EMB-07 binds to both ROR1 expressed on tumor cells and CD3 expressed on cytotoxic T lymphocytes (CTLs). This activates and redirects CTLs to ROR1-expressing tumor cells, which results in the CTL-mediated death of ROR1-expressing tumor cells. ROR1, also known as neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), is expressed during embryogenesis and in many types of hematological malignancies. It plays key roles in tumor cell proliferation and survival.",
  "synonyms": [
    "anti-ROR1/CD3 bispecific antibody EMB-07",
    "ROR1 x CD3 bispecific antibody EMB-07"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-ror1-anti-cd3-bispecific-antibody-emb-07/"
}