Autologous CD138-specific CAR T cells

{
  "id": "MLC-T-ONC-011533",
  "term": "Autologous CD138-specific CAR T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that have been engineered to express a chimeric antigen receptor (CAR) specific for syndecan-1 (CD138), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous CD138 CAR-expressing T cells target and induce selective toxicity in syndecan-1-expressing tumor cells. Syndecan-1, a type 1 transmembrane proteoglycan and tumor-associated antigen (TAA), is overexpressed in a variety of cancer cells and plays a key role in the regulation of cell growth, differentiation, and adhesion.",
  "synonyms": [
    "autologous CD138-specific CAR T lymphocytes",
    "autologous syndecan-1-specific CAR T lymphocytes",
    "autologous syndecan-1-sepcific CAR T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-cd138-specific-car-t-cells/"
}