XBP1-US/XBP1-SP/CD138/CS1 multipeptide vaccine PVX-410

{
  "id": "MLC-T-ONC-017593",
  "term": "XBP1-US/XBP1-SP/CD138/CS1 multipeptide vaccine PVX-410",
  "field": "Oncology and biomedicine",
  "definition": "A cancer vaccine containing immunogenic, HLA-A2-specific epitopes derived from X-box-binding protein 1-unspliced (XBP1-US), XBP1-spliced (SP), syndecan-1 (CD138), and CS1 (CD2 subset 1, CRACC, SLAMF7, CD319) with potential immunomodulating and antineoplastic activities. Upon subcutaneous administration, XBP1-US/XBP1-SP/CD138/CS1 multipeptide vaccine PVX-410 may stimulate the immune system to induce a cytotoxic T-lymphocyte response against the four myeloma-specific antigens. The tumor associated antigens (TAAs) XBP1-US, XBP1-SP, CD138 and CS1, are overexpressed on the surface of multiple myeloma (MM) cells.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/xbp1-us-xbp1-sp-cd138-cs1-multipeptide-vaccine-pvx-410/"
}