autologous neuroblastoma lysate/KLH-pulsed dendritic cell vaccine

{
  "id": "MLC-T-ONC-011716",
  "term": "autologous neuroblastoma lysate/KLH-pulsed dendritic cell vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A cell-based cancer vaccine composed of autologous dendritic cells (DCs) pulsed with a cell lysate from an autologous neuroblastoma containing tumor-associated antigens (TAAs) and the immunostimulant keyhole limpet hemocyanin (KLH), with potential immunostimulatory and antineoplastic activities. Upon administration, autologous neuroblastoma lysate/KLH-pulsed DC vaccine may stimulate the immune system to mount an anti-tumoral cytotoxic T-lymphocyte (CTL) response against neuroblastoma cells, which may result in tumor cell lysis. KLH is an immunogenic carrier and serves as an immunostimulant to improve antigenic immune recognition and T-cell responses.",
  "synonyms": [
    "autologous neuroblastoma lysate/KLH-pulsed DC vaccine",
    "keyhole limpet hemocyanin-pulsed dendritic cell vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-neuroblastoma-lysate-klh-pulsed-dendritic-cell-vaccine/"
}