Autologous neoantigen-specific T lymphocytes GEN-011

{
  "id": "MLC-T-ONC-011715",
  "term": "Autologous neoantigen-specific T lymphocytes GEN-011",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous, personalized, immunogenic and tumor neoantigen-specific T lymphocytes, with potential immunostimulating and antineoplastic activities. Tumor-specific neoantigen targets of autologous CD4+ and/or CD8+ T cells are identified and T cells that target immunogenic and stimulatory neoantigens are expanded ex vivo. Upon administration, the autologous neoantigen-specific T lymphocytes GEN-011 recognize and bind to tumor cells expressing the targeted neoantigens, resulting in a cytotoxic T-lymphocyte (CTL)-mediated immune response against the patient's tumor cells.",
  "synonyms": [
    "autologous immunogenic neoantigen-specific T cells GEN-011",
    "autologous neoantigen-targeting T cells GEN-011"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-neoantigen-specific-t-lymphocytes-gen-011/"
}