CD4-specific telomerase peptide vaccine UCPVax

{
  "id": "MLC-T-ONC-012414",
  "term": "CD4-specific telomerase peptide vaccine UCPVax",
  "field": "Oncology and biomedicine",
  "definition": "A therapeutic peptide vaccine containing the human telomerase reverse transcriptase catalytic subunit (hTERT)-derived universal cancer peptides 2 (UCP2) and 4 (UCP4), and combined with the immunoadjuvant Montanide ISA 51 VG, with potential immunostimulating and antineoplastic activities. Vaccination with the CD4-specific telomerase peptide vaccine UCPVax activates the immune system to mount a T-helper 1 (TH1) CD4-positive T-lymphocyte immune response against and ultimately killing telomerase-expressing cells. Telomerase, a reverse transcriptase normally repressed in healthy cells, is overexpressed in most cancer cells and plays a key role in cellular proliferation.",
  "synonyms": [
    "UCP2/UCP4 CD4-specific telomerase peptide vaccine UCPVax"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cd4-specific-telomerase-peptide-vaccine-ucpvax/"
}