Clofarabine

{
  "id": "MLC-T-ONC-001844",
  "term": "Clofarabine",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to treat children and young adults aged 1 to 21 years with acute lymphoblastic leukemia. It is used in patients whose cancer came back or did not get better after at least two other types of anticancer treatment. It is also being studied in the treatment of other types of cancer. Clofarabine stops cells from making DNA and may kill cancer cells. It is a type of antimetabolite. Also called Clolar.",
    "A second generation purine nucleoside analog with antineoplastic activity. Clofarabine is phosphorylated intracellularly to the cytotoxic active 5'-triphosphate metabolite, which inhibits the enzymatic activities of ribonucleotide reductase and DNA polymerase, resulting in inhibition of DNA repair and synthesis of DNA and RNA. This nucleoside analog also disrupts mitochondrial function and membrane integrity, resulting in the release of pre-apoptotic factors, including cytochrome C and apoptotic-inducing factors, which activate apoptosis."
  ],
  "abbreviation": "CAFdA",
  "synonyms": [
    "Clolar"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/clofarabine/"
}