contusugene ladenovec

{
  "id": "MLC-T-ONC-012727",
  "term": "contusugene ladenovec",
  "field": "Oncology and biomedicine",
  "definition": "A replication-defective adenoviral-CMV vector that encodes a wild-type p53 gene. Contusugene ladenovec induces tumor cells that have been transfected with the vector to produce wild-type p53, a tumor suppressor gene that is deleted or mutated in a significant number of cancers. In transfected tumor cells, the wild-type p-53 gene product exerts an antitumor effect by blocking cell cycle progression at the G1/S regulation point, activating DNA repair proteins in the presence of DNA damage, and initiating apoptosis when DNA damage is irreparable.",
  "abbreviation": "Ad5CMV-p53",
  "synonyms": [
    "Ad5CMV-p53 gene",
    "adeno-p53",
    "adenovirus p53",
    "p53 gene, Ad5CMV"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/contusugene-ladenovec/"
}