Fluorine F 18 DASA-23

{
  "id": "MLC-T-ONC-013666",
  "term": "Fluorine F 18 DASA-23",
  "field": "Oncology and biomedicine",
  "definition": "A radiotracer composed of DASA-23, a pyruvate kinase isoform M2 (PKM2) ligand, conjugated to the radioisotope fluorine F 18, with potential use for imaging of PKM2-expressing tumor cells upon positron emission tomography (PET). Upon administration of fluorine F 18 DASA-23, the DASA-23 moiety selectively targets and is taken up by tumor cells that express PKM2. Upon binding to PKM2 and following PET, PKM2-expressing tumor cells can be visualized and the metabolic activity of the tumor cells can be assessed through the quantitation of PKM2 expression levels. PKM2, an enzyme that plays a key role in the glycolytic reprogramming, metabolic activity and rapid proliferation of tumor cells, is selectively overexpressed in various tumor cell types. Tumor uptake of fluorine F 18 DASA-23 is positively correlated with PKM2 expression.",
  "synonyms": [
    "F18-labeled PKM2 inhibitor DASA-23",
    "18F-DASA-23",
    "F18-labeled pyruvate kinase M2 inhibitor DASA-23"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/fluorine-f-18-dasa-23/"
}