Fluorine F 18 florilglutamic acid

{
  "id": "MLC-T-ONC-013674",
  "term": "Fluorine F 18 florilglutamic acid",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of the radionuclide fluorine F 18 conjugated to the florilglutamic acid that targets the cystine/glutamate transporter protein (xCT or SLC7A11), which is a subunit of the transport system xc(-), with potential imaging activity upon positron emission tomography (PET). Upon intravenous administration, fluorine F 18 florilglutamic acid specifically binds to xCT and is subsequently taken up by the cell via xc(-). Upon uptake, xc(-) activity can be assessed and tumor cells can be detected and imaged by PET. System xc(-), a sodium-independent, heterodimeric transporter, mediates the cellular uptake of cystine in exchange for intracellular glutamate at the plasma membrane; although, it will take up glutamate as well. Xc(-) shows increased activity in certain tumor cells compared to normal, healthy cells due to increased metabolic activity in tumor cells; it plays a key role in tumor cell proliferation, progression and chemoresistance as well as in the management of oxidative stress.",
  "synonyms": [
    "fluorine F 18 L-glutamate derivative BAY94-9392",
    "(S)-4-(3-18F-fluoropropyl)-L-glutamic acid"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/fluorine-f-18-florilglutamic-acid/"
}