fluorine F 18 LY3546117

{
  "id": "MLC-T-ONC-013688",
  "term": "fluorine F 18 LY3546117",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of the granzyme B-targeting agent LY3546117 labeled with the radionuclide fluorine F 18, with potential use as an imaging agent for granzyme B activity upon positron emission tomography (PET). Upon administration, fluorine F 18 LY3546117 targets and binds to granzyme B. Granzyme B activity can then be visualized using PET. Granzyme B plays a key role in cytotoxic T-lymphocyte (CTL)- and natural killer (NK) cell-mediated cytotoxicity of virus-infected cells and tumor cells.",
  "synonyms": [
    "18F-LY3546117"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/fluorine-f-18-ly3546117/"
}