granisetron hydrochloride nasal spray

{
  "id": "MLC-T-ONC-014028",
  "term": "granisetron hydrochloride nasal spray",
  "field": "Oncology and biomedicine",
  "definition": "An intranasal formulation containing the hydrochloride salt form of the indazole derivative granisetron, a selective serotonin (5-hydroxytryptamine; 5-HT) receptor antagonist, with antinauseant and antiemetic activities. Upon administration to the nostril, granisetron selectively binds to and inhibits 5-HT subtype 3 receptors (5-HT3R) located peripherally on vagus nerve terminals and centrally in the chemoreceptor trigger zone (CTZ) of the area postrema, which may result in suppression of chemotherapy-induced nausea and vomiting (CINV).",
  "abbreviation": "GNS",
  "synonyms": [
    "intranasal granisetron hydrochloride",
    "granisetron HCl nasal spray"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/granisetron-hydrochloride-nasal-spray/"
}