Gwt1 inhibitor APX001

{
  "id": "MLC-T-ONC-014050",
  "term": "Gwt1 inhibitor APX001",
  "field": "Oncology and biomedicine",
  "definition": "An orally available small molecule inhibitor of the Gwt1 fungal enzyme with potential antifungal activity. Upon administration APX001, a N-phosphonooxymethyl prodrug, is rapidly and completely metabolized by systemic alkaline phosphatases to its active moiety, APX001A (E1210). The active prodrug targets Gwt1, a highly conserved inositol acylase which catalyzes an essential step in the glycosylphosphatidylinositol (GPI)-anchor biosynthesis pathway. Inhibition of Gwt1 prevents localization of cell wall mannoproteins, which compromises cell wall integrity, biofilm formation, germ tube formation, and fungal growth.",
  "synonyms": [
    "prodrug APX001"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gwt1-inhibitor-apx001/"
}