Listeria monocytogenes-LLO-prostate cancer neoantigens vaccine ADXS-504

{
  "id": "MLC-T-ONC-014847",
  "term": "Listeria monocytogenes-LLO-prostate cancer neoantigens vaccine ADXS-504",
  "field": "Oncology and biomedicine",
  "definition": "An off-the-shelf (OTS) cancer vaccine containing a live-attenuated strain of the Gram-positive bacterium Listeria monocytogenes (Lm) encoding a fusion protein composed of specific prostate cancer (PC) neoantigens fused to a fragment of the immunostimulant listeriolysin O (LLO) protein, with potential immunostimulatory and antineoplastic activities. Upon administration of the Lm-LLO-PC neoantigens vaccine ADXS-504, the expressed LLO-PC neoantigens is processed by antigen presenting cells (APCs), presented to the immune system by both major histocompatibility complex (MHC) I and II molecules, and activates the immune system to exert both an innate and adaptive immune response involving the recruitment and activation of T lymphocytes against neoantigen-expressing prostate cancer cells as well as the inhibition of tumor-infiltrating T regulatory cells (T regs) and myeloid-derived suppressor cells (MDSCs). This further modulates the tumor microenvironment (TME) and further results in tumor cell eradication. The neoantigens in ADXS-504 are composed of public hotspot mutations and proprietary tumor associated antigen (TAAs).",
  "synonyms": [
    "Listeria monocytogenes-LLO-PC neoantigens vaccine ADXS-504",
    "Lm-LLO-PC neoantigens vaccine ADXS-504",
    "Lm-LLO-prostate cancer neoantigens ADXS-504"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/listeria-monocytogenes-llo-prostate-cancer-neoantigens-vaccine-adxs-504/"
}