live-attenuated Listeria monocytogenes encoding EGFRvIII-NY-ESO-1 vaccine ADU-623

{
  "id": "MLC-T-ONC-014854",
  "term": "live-attenuated Listeria monocytogenes encoding EGFRvIII-NY-ESO-1 vaccine ADU-623",
  "field": "Oncology and biomedicine",
  "definition": "A live-attenuated, double-deleted strain of the Gram-positive bacterium Listeria monocytogenes (Lm) encoding a mutant form of the tumor-associated antigens, epidermal growth factor receptor (EGFRvIII) and the cancer/testis antigen NY-ESO-1, with potential immunostimulatory and antineoplastic activities. Upon intravenous administration, live-attenuated Listeria monocytogenes encoding EGFRvIII-NY-ESO-1 vaccine targets dendritic cells and expresses EGFRvIII and NY-ESO-1. This promotes both a potent innate immune response and an adaptive immune response involving the recruitment and activation of T lymphocytes against EGFRvIII and NY-ESO-1-expressing tumor cells, which results in tumor cell lysis.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/live-attenuated-listeria-monocytogenes-encoding-egfrviii-ny-eso-1-vaccine-adu/"
}