menin inhibitor DS-1594b

{
  "id": "MLC-T-ONC-015091",
  "term": "menin inhibitor DS-1594b",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable small molecule inhibitor of menin, with potential antineoplastic activity. Upon oral administration, menin inhibitor DS-1594b targets and binds to the nuclear protein menin, thereby preventing the interaction between the two proteins menin and menin-mixed lineage leukemia (MLL; myeloid/lymphoid leukemia; KMT2A) and the formation of the menin-MLL complex. This reduces the expression of downstream target genes and results in an inhibition of the proliferation of MLL-rearranged leukemic cells. The menin-MLL complex plays a key role in the survival, growth, transformation and proliferation of certain kinds of leukemia cells.",
  "synonyms": [
    "menin-MLL interaction inhibitor DS-1594b"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/menin-inhibitor-ds-1594b/"
}