menin-MLL interaction inhibitor JNJ-75276617

{
  "id": "MLC-T-ONC-015093",
  "term": "menin-MLL interaction inhibitor JNJ-75276617",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable protein-protein interaction (PPI) inhibitor of the menin-mixed lineage leukemia (MLL; mixed-lineage leukemia 1; MLL1; myeloid/lymphoid leukemia; histone-lysine N-methyltransferase 2A; KMT2A) proteins, with potential antineoplastic activity. Upon oral administration, menin-MLL interaction inhibitor JNJ-75276617 inhibits the interaction between the two proteins menin and MLL and the formation of the menin-MLL complex. This reduces the expression of downstream target genes and results in an inhibition of the proliferation of leukemic cells with either KMT2A alterations such as gene rearrangements (KMT2A-r), duplications, and amplification, or nucleophosmin 1 gene (NPM1) alterations. The menin-MLL complex plays a key role in the survival, growth, transformation and proliferation of certain kinds of leukemia cells.",
  "synonyms": [
    "Menin-MLL1 interaction inhibitor JNJ-75276617",
    "menin-KMT2A interaction inhibitor JNJ-75276617"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/menin-mll-interaction-inhibitor-jnj-75276617/"
}