MTF-1 inhibitor APTO-253 HCl

{
  "id": "MLC-T-ONC-015315",
  "term": "MTF-1 inhibitor APTO-253 HCl",
  "field": "Oncology and biomedicine",
  "definition": "The hydrochloride salt of a small molecule inhibitor of human metal-regulatory transcription factor 1 (MTF-1) with potential antitumor activity. MTF-1 inhibitor APTO-253 inhibits MTF-1 activity and thereby induces the expression of MTF-1 dependent tumor suppressor factor Kruppel like factor 4 (KLF4). This subsequently leads to the downregulation of cyclin D1, blocking cell cycle progression and proliferation. This agent also causes decreased expression of genes involved in tumor hypoxia and angiogenesis.",
  "synonyms": [
    "MTF-1 inhibitor LOR-253 HCl"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/mtf-1-inhibitor-apto-253-hcl/"
}