MUC-1 antigen

{
  "id": "MLC-T-ONC-015327",
  "term": "MUC-1 antigen",
  "field": "Oncology and biomedicine",
  "definition": "MUC-1 antigen is a mammary-type apomucin, a high molecular weight transmembrane glycoprotein, of which the extracellular domain is formed by a repeating 20 amino acid sequence (in tandem) with a high content of serine and threonine on which are O-linked carbohydrate chains. MUC-1 synthesis and secretion are features of glandular epithelial tissues; MUC-1 is overexpressed in lactating breast and in breast, ovary, lung, and prostate malignancies.",
  "abbreviation": "MAM-6",
  "synonyms": [
    "CA15-3 antigen",
    "cancer antigen 15-3",
    "DF3 antigen",
    "episialin",
    "glycosylated MUC-1",
    "ImMucin",
    "Muc1 mucin",
    "mucin peptide MUC-1",
    "polymorphic epithelial mucin",
    "MUC-1",
    "mucin antigen",
    "sialylated MUC-1"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/muc-1-antigen/"
}