Oblimersen sodium

{
  "id": "MLC-T-ONC-005998",
  "term": "Oblimersen sodium",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A substance being studied in the treatment of cancer. It may kill cancer cells by blocking the production of a protein that makes cancer cells live longer and by making them more sensitive to anticancer drugs. It is a type of antisense oligodeoxyribonucleotide. Also called augmerosen, bcl-2 antisense oligodeoxynucleotide G3139, and Genasense.",
    "The sodium salt of a phosphorothioate antisense oligonucleotide targeted to the initiation codon region of mRNA for the anti-apoptotic gene Bcl-2. Oblimersen inhibits Bcl-2 mRNA translation, which may result in decreased expression of the Bcl-2 protein and tumor cell apoptosis. This agent may enhance the efficacy of standard cytotoxic chemotherapy. The anti-apoptotic bcl-2 protein is an integral outer mitochondrial membrane protein (OMMP) that is overexpressed in some cancer cell types and is linked to tumor drug resistance."
  ],
  "synonyms": [
    "augmerosen",
    "bcl-2 antisense oligodeoxynucleotide G3139",
    "Genasense",
    "antidode G3139",
    "BCL-2 antisense/G3139",
    "G3139 antisense oligonucleotide",
    "G3139 bcl-2 antisense oligo",
    "G3139 bcl-2 antisense oligodeoxynucleotide",
    "G3139 bcl-2 antisense oligonucleotide"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/oblimersen-sodium/"
}