oxaliplatin

{
  "id": "MLC-T-ONC-006220",
  "term": "oxaliplatin",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used with other drugs to treat stage III colon cancer that was removed by surgery and colorectal cancer that is advanced. It is also being studied in the treatment of other types of cancer. Oxaliplatin damages the cell’s DNA and may kill cancer cells. It is a type of platinum compound. Also called Eloxatin.",
    "An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane (DACH) and with an oxalate ligand as a 'leaving group.' A 'leaving group' is an atom or a group of atoms that is displaced as a stable species taking with it the bonding electrons. After displacement of the labile oxalate ligand leaving group, active oxaliplatin derivatives, such as monoaquo and diaquo DACH platinum, alkylate macromolecules, forming both inter- and intra-strand platinum-DNA crosslinks, which result in inhibition of DNA replication and transcription and cell-cycle nonspecific cytotoxicity. The DACH side chain appears to inhibit alkylating-agent resistance."
  ],
  "abbreviation": "L-OHP",
  "synonyms": [
    "Eloxatin",
    "diaminocyclohexane oxalatoplatinum",
    "oxalatoplatin",
    "oxalatoplatinum",
    "oxaliplatine",
    "Aiheng",
    "Ai Heng"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/oxaliplatin/"
}