Pibrozelesin

{
  "id": "MLC-T-ONC-016063",
  "term": "Pibrozelesin",
  "field": "Oncology and biomedicine",
  "definition": "A semisynthetic water-soluble derivative of the antineoplastic antibiotic duocarmycin B2. Activated by carboxyl esterase, pibrozelesin alkylates DNA by binding to adenine-thymine (A-T)-rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and inducing apoptosis.",
  "synonyms": [
    "Duocamycin B2 Analog"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/pibrozelesin/"
}