MLchartDataset catalogue

piperazinedione

Term · Oncology and biomedicine · MLC-T-ONC-016087

A crystalline antibiotic fermentation product isolated from the bacterium Streptomyces griseoluteus with antineoplastic activity. Piperazinedione alkylates DNA at the N-7 position of guanine, inhibiting DNA replication and inducing cell cycle arrest.

Table 1. Record
IdentifierMLC-T-ONC-016087
FieldOncology and biomedicine
AbbreviationPZD
Synonymscompound 593A; Merck Compound 593A;
ReferencesNational Cancer Institute Thesaurus (CC BY 4.0)
Record as JSON 
{
  "id": "MLC-T-ONC-016087",
  "term": "piperazinedione",
  "field": "Oncology and biomedicine",
  "definition": "A crystalline antibiotic fermentation product isolated from the bacterium Streptomyces griseoluteus with antineoplastic activity. Piperazinedione alkylates DNA at the N-7 position of guanine, inhibiting DNA replication and inducing cell cycle arrest.",
  "abbreviation": "PZD",
  "synonyms": [
    "compound 593A",
    "Merck Compound 593A;"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/piperazinedione/"
}

Record 13,273 of 17,721 in Oncology and biomedicine terminology (MLC-0111). Request the full dataset.