Plicamycin

{
  "id": "MLC-T-ONC-006755",
  "term": "Plicamycin",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to treat some types of testicular cancer. It is also used to treat a higher-than-normal amounts of calcium in the blood or urine. Plicamycin binds to DNA and prevents cells from making RNA and proteins. It is a type of antineoplastic antibiotic. Also called Mithracin and mithramycin.",
    "An antibiotic isolated from the bacterium Streptomyces plicatus with antineoplastic activity. Plicamycin, also known as mithramycin, binds to the minor groove of DNA at GC-rich sites, resulting in inhibition of RNA synthesis; this agent also inhibits mRNA expression, resulting in a reduction in protein synthesis. In addition, plicamycin may inhibit bone resorption by down regulating transcription of c-src, an oncogene involved in bone metabolism and resorption."
  ],
  "abbreviation": "MTH",
  "synonyms": [
    "Mithracin",
    "mithramycin",
    "aureolic acid"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/plicamycin/"
}