Procarbazine hydrochloride

{
  "id": "MLC-T-ONC-006933",
  "term": "Procarbazine hydrochloride",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used with other drugs to treat advanced Hodgkin lymphoma. It is also being studied in the treatment of other types of cancer. Procarbazine hydrochloride damages the cell’s DNA and may kill cancer cells. It is a type of alkylating agent. Procarbazine is the active ingredient of procarbazine hydrochloride. Also called Matulane.",
    "The hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction."
  ],
  "abbreviation": "PCB",
  "synonyms": [
    "Matulane",
    "ibenzmethyzin hydrochloride",
    "MIH hydrochloride",
    "PCB hydrochloride",
    "PCZ"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/procarbazine-hydrochloride/"
}