RBM39 degrader REC-1245

{
  "id": "MLC-T-ONC-016378",
  "term": "RBM39 degrader REC-1245",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable molecular glue degrader of the splicing factor RNA-binding protein 39 (RNA-binding motif protein 39; RBM39), with potential antineoplastic activity. Upon oral administration, RBM39 degrader REC-1245 induces the ubiquitination and proteasome-mediated degradation of RBM39 via the E3 ligase adaptor DCAF15. This modulates RNA splicing, prevents the expression of certain tumor-associated genes, and downregulates DNA damage response (DDR) networks and cell cycle checkpoints including cyclin-dependent kinase 12 (CDK12), which may inhibit tumor cell proliferation. RBM39, overexpressed in many cancers, plays an important role in alternative splicing and regulating the transcription of many tumor-related genes.",
  "synonyms": [
    "RBM39 molecular glue degrader REC-1245"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/rbm39-degrader-rec-1245/"
}