estrogen receptor degrader AC699

{
  "id": "MLC-T-ONC-013442",
  "term": "estrogen receptor degrader AC699",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable estrogen receptor (ER)-targeted chimeric protein degrader composed of ligands of ER and cereblon (CRBN) E3 ubiquitin ligase, with potential antineoplastic activity. Upon oral administration of ER degrader AC699, the ER-targeting moiety targets and binds to ER, and the CRBN-binding moiety recruits CRBN, a component of the CRL4-CRBN E3 ubiquitin ligase complex. This catalyzes ubiquitination and proteasome-mediated degradation of ER, prevents ER-mediated signaling, and inhibits both the growth and survival of ER-expressing cancer cells. ER is overexpressed in a variety of cancers and plays a key role in cancer cell proliferation.",
  "synonyms": [
    "ER degrader AC699",
    "ER-targeting chimeric protein degrader AC699"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/estrogen-receptor-degrader-ac699/"
}