ER alpha-targeting chimeric protein degrader AC682

{
  "id": "MLC-T-ONC-013401",
  "term": "ER alpha-targeting chimeric protein degrader AC682",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable, selective estrogen receptor (ER) alpha-targeted chimeric protein degrader, with potential antineoplastic activity. Upon oral administration, ER alpha-targeting chimeric protein degrader AC682 targets ER alpha wild-type and mutants and induces the degradation of ER alpha proteins. This decreases ER alpha protein levels, decreases the expression of ER alpha-target genes and halts ER-mediated signaling. This results in an inhibition of proliferation in ER alpha-overexpressing tumor cells. ER alpha is overexpressed in a variety of cancers and plays a key role in cancer cell proliferation. AC682 is able to cross the blood-brain barrier (BBB).",
  "synonyms": [
    "ERa degrader AC0682",
    "estrogen receptor alpha-targeting chimeric protein degrader AC0682",
    "ER degrader AC0682",
    "ER-alpha protein degrader AC0682"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/er-alpha-targeting-chimeric-protein-degrader-ac682/"
}