Rilimogene glafolivec

{
  "id": "MLC-T-ONC-016544",
  "term": "Rilimogene glafolivec",
  "field": "Oncology and biomedicine",
  "definition": "A cancer vaccine consisting of a recombinant fowlpox virus encoding fragment of human prostate-specific antigen (PSA), PSA:154-163 (155L), and a TRIad of COstimulatory Molecules (B7-1, ICAM-1 and LFA-3) (TRICOM). Administration of this agent may induce a cytotoxic T cell response against PSA-expressing tumor cells. Dendritic cells infected with TRICOM vectors greatly enhance naive T-cell activation and peptide-specific T-cell stimulation. Fowlpox virus is an attractive vector because its genome is easy to manipulate and it is replication incompetent in mammalian cells.",
  "synonyms": [
    "PROSTVAC-F",
    "recombinant fowlpox-PSA(L155)/TRICOM vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/rilimogene-glafolivec/"
}