rolapitant hydrochloride

{
  "id": "MLC-T-ONC-007487",
  "term": "rolapitant hydrochloride",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used with other drugs in adults to prevent nausea and vomiting caused by chemotherapy. Rolapitant hydrochloride blocks the action of a certain chemical in the central nervous system that may trigger nausea and vomiting. Blocking this chemical may lessen nausea and vomiting. Rolapitant hydrochloride is a type of antiemetic and a type of substance P/neurokinin 1 receptor antagonist. Also called Varubi.",
    "The hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. Upon oral administration, rolapitant competitively binds to and blocks the activity of the NK1-receptor in the central nervous system, thereby inhibiting the binding of the endogenous ligand, substance P (SP). This may prevent both SP-induced emesis and chemotherapy-induced nausea and vomiting (CINV). The interaction of SP with the NK1-receptor plays a key role in the induction of nausea and vomiting caused by emetogenic cancer chemotherapy. Compared to other NK1-receptor antagonists, rolapitant has both a more rapid onset of action and a much longer half-life."
  ],
  "synonyms": [
    "Varubi",
    "rolapitant hydrochloride monohydrate",
    "rolapitant monohydrochloride monohydrate",
    "rolapitant HCl"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/rolapitant-hydrochloride/"
}