aprepitant

{
  "id": "MLC-T-ONC-000694",
  "term": "aprepitant",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used with other drugs to prevent nausea and vomiting caused by chemotherapy and nausea and vomiting after surgery. Aprepitant blocks the action of a certain chemical in the central nervous system that may trigger nausea and vomiting. Blocking this chemical may help lessen nausea and vomiting. Aprepitant is a type of antiemetic and a type of substance P/neurokinin 1 receptor antagonist. Also called Cinvanti and Emend.",
    "A small molecule, high-affinity substance P antagonist (SPA) with antiemetic activity. Crossing the blood brain barrier, aprepitant binds selectively to the human substance P/neurokinin 1 receptor in the central nervous system (CNS), thereby inhibiting receptor binding of endogenous substance P and substance P-induced emesis. This agent has little or no affinity for serotonin type 3 (5-HT3), dopamine, and corticosteroid receptors."
  ],
  "synonyms": [
    "Cinvanti",
    "Emend"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/aprepitant/"
}