rubitecan

{
  "id": "MLC-T-ONC-016597",
  "term": "rubitecan",
  "field": "Oncology and biomedicine",
  "definition": "A semisynthetic agent related to camptothecin with potent antitumor and antiviral properties. Rubitecan binds to and inhibits the enzyme topoisomerase I and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells; this agent also prevents repair of reversible single-strand DNA breaks.",
  "abbreviation": "9-NC",
  "synonyms": [
    "9-nitro-CPT",
    "9-nitrocamptothecin",
    "nitrocamptothecin"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/rubitecan/"
}