Aerosolized liposomal rubitecan

{
  "id": "MLC-T-ONC-009721",
  "term": "Aerosolized liposomal rubitecan",
  "field": "Oncology and biomedicine",
  "definition": "An aerosolized liposomal preparation of rubitecan, a water-insoluble derivative of camptothecin with potential antineoplastic activity. Rubitecan (or 9-nitro-20 (S)-camptothecin) and its active metabolite 9-aminocamptothecin (9-AC) selectively stabilize topoisomerase I-DNA covalent complexes during S-phase, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. This agent is formulated with dilauroylphosphatidylcholine and nebulized in particle sizes of 1.2-1.6 micrometer mass median aerodynamic diameter.",
  "synonyms": [
    "aerosolized liposomal 9-nitrocamptothecin",
    "aerosolized liposomal 9-nitro-20(S)-camptothecin"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/aerosolized-liposomal-rubitecan/"
}