single nucleotide polymorphism

{
  "id": "MLC-T-ONC-007778",
  "term": "single nucleotide polymorphism",
  "field": "Oncology and biomedicine",
  "definitions": [
    "The most common type of change in DNA (molecules inside cells that carry genetic information). Single nucleotide polymorphisms occur when a single nucleotide (building block of DNA) is replaced with another. These changes may cause disease, and may affect how a person reacts to bacteria, viruses, drugs, and other substances. Also called SNP.",
    "A DNA sequence variation that occurs when a single nucleotide (adenine, thymine, cytosine, or guanine) is different from the reference sequence. Single nucleotide polymorphisms are usually present in at least 1% of the population and are the most common type of genetic variation among people. Single nucleotide polymorphisms may increase the risk of developing certain diseases, act as biomarkers to help predict the risk of developing certain diseases or how a person may respond to certain drugs, or be used to track the inheritance of disease-causing variants within families. Also called SNP."
  ],
  "synonyms": [
    "SNP"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "NCI Dictionary of Genetics Terms"
  ],
  "url": "https://mlchart.com/terminology/oncology/single-nucleotide-polymorphism/"
}