Thorium Th 227 anetumab corixetan

{
  "id": "MLC-T-ONC-017147",
  "term": "Thorium Th 227 anetumab corixetan",
  "field": "Oncology and biomedicine",
  "definition": "A radioimmunoconjugate consisting of anetumab, a human immunoglobulin G1 (IgG1) monoclonal antibody directed against the cell surface glycoprotein mesothelin, conjugated to the chelating agent corixetan, and labeled with the alpha-emitting radioisotope thorium Th 227, with potential antineoplastic activity. Upon administration of thorium Th 227 anetumab corixetan, the anetumab moiety binds to the tumor-associated antigen (TAA) mesothelin, delivering a cytotoxic dose of alpha radiation to cells expressing mesothelin.",
  "synonyms": [
    "thorium-227-labeled antibody-chelator conjugate BAY2287411",
    "thorium Th 227 monoclonal antibody BAY2287411",
    "thorium-227-labeled anetumab",
    "227Th anetumab corixetan"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/thorium-th-227-anetumab-corixetan/"
}