thorium Th 227 anti-PSMA monoclonal antibody BAY 2315497

{
  "id": "MLC-T-ONC-017149",
  "term": "thorium Th 227 anti-PSMA monoclonal antibody BAY 2315497",
  "field": "Oncology and biomedicine",
  "definition": "A radioimmunoconjugate consisting of a monoclonal antibody targeting the tumor-associated antigen (TAA) human prostate-specific membrane antigen (PSMA) and labeled, via a 3-hydroxypyridin-2-one (3,2-HOPO) chelator, with the alpha-emitting radioisotope thorium Th 227, with potential antineoplastic activity. Upon administration, the monoclonal antibody moiety of BAY 2315497 targets and specifically binds to PSMA on tumor cells, delivering a cytotoxic dose of alpha radiation to cells expressing PSMA. PSMA is overexpressed on the surface of metastatic and hormone-refractory prostate cancer cells.",
  "synonyms": [
    "PSMA-targeted thorium-227 conjugate BAY-2315497",
    "PSMA-TTC BAY 2315497",
    "targeted thorium conjugate BAY 2315497",
    "Th 227 anti-PSMA monoclonal antibody BAY 2315497",
    "thorium Th 227 monoclonal antibody BAY 2315497",
    "thorium-227 anti-PSMA monoclonal antibody BAY 2315497",
    "thorium-227-labeled antibody-chelator conjugate BAY 2315497",
    "thorium-227 labeled immunoconjugate BAY-2315497"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/thorium-th-227-anti-psma-monoclonal-antibody-bay-2315497/"
}