thorium Th 227 anti-HER2 monoclonal antibody BAY2701439

{
  "id": "MLC-T-ONC-017148",
  "term": "thorium Th 227 anti-HER2 monoclonal antibody BAY2701439",
  "field": "Oncology and biomedicine",
  "definition": "A radioimmunoconjugate consisting of a monoclonal antibody targeting the tyrosine kinase receptor epidermal growth factor receptor 2 (HER2; ErbB2) and labeled with the alpha-emitting radioisotope thorium Th 227, with potential antineoplastic activity. Upon administration, the monoclonal antibody moiety of BAY2701439 targets and specifically binds to HER2 on tumor cells, delivering a cytotoxic dose of alpha radiation to cells expressing HER2. HER2 is overexpressed in a variety of cancer cell types and is associated with increased tumor cell proliferation.",
  "synonyms": [
    "227Th anti-HER2 monoclonal antibody BAY2701439",
    "Th 227 anti-HER2 monoclonal antibody BAY2701439",
    "Th-227-anti-HER2 monoclonal antibody BAY2701439",
    "thorium Th 227 MOAB BAY2701439",
    "thorium Th 227 monoclonal antibody BAY2701439",
    "thorium-227 anti-HER2 monoclonal antibody BAY2701439"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/thorium-th-227-anti-her2-monoclonal-antibody-bay2701439/"
}