Automated cryogenic storage system

{
  "publication_number": "US10661990B2",
  "country": "US",
  "kind": "B2",
  "title": "Automated cryogenic storage system",
  "abstract": "An automated cryogenic storage system includes a freezer and an automation system to provide automated transfer of samples to and from the freezer. The freezer includes a bearing and a drive shaft though the freezer, the drive shaft being coupled to a rack carrier inside the freezer and adapted to be coupled to a motor. The automation module includes a rack puller that is automatically positioned above an access port of the freezer. The rack puller engages with a sample rack within the freezer, and elevates the rack into an insulating sleeve external to the freezer. From the insulating sleeve, samples can be added to and removed from the sample rack before it is returned to the freezer.",
  "claims": [
    "1. A device for engaging with a sample rack, comprising: a bracket configured to be coupled with an automated retrieval system; a gripping module configured to engage with a mounting surface of the sample rack; a shaft extending between the bracket and the gripping module; and at least one moisture diverter configured to direct moisture away from the gripping module; wherein the at least one moisture diverter includes a drip shield including angled leaves configured to direct moisture away from a bottom surface of the gripping module.",
    "2. The device of claim 1, wherein the gripping module further includes a latch configured to lock selectively with the mounting surface.",
    "3. The device of claim 2, further comprising a seal encompassing the rod at a location within the shaft and adjacent to a top portion of the gripping module.",
    "4. The device of claim 1, wherein the gripping module further includes at least one spacer pin extending downward from a bottom surface of the gripping module, the at least one spacer pin configured to contact the mounting surface of the sample rack when the gripping module is engaged with the mounting surface.",
    "5. The device of claim 4, wherein the at least one spacer pin is further configured to prevent contact between the bottom surface of the gripping module and the mounting surface when the gripping module is engaged with the mounting surface.",
    "6. The device of claim 1, wherein the moisture includes liquid moisture.",
    "7. A device for engaging with a sample rack, comprising: a bracket configured to be coupled with an automated retrieval system; a gripping module configured to engage with a mounting surface of the sample rack; a shaft extending between the bracket and the gripping module; and at least one moisture diverter configured to direct moisture away from the gripping module; wherein the gripping module further includes a latch configured to lock selectively with the mounting surface; wherein the latch is configured to be controlled via rotation of a rod located within the shaft.",
    "8. A device for engaging with a sample rack, comprising: a bracket configured to be coupled with an automated retrieval system; a gripping module configured to engage with a mounting surface of the sample rack; a shaft extending between the bracket and the gripping module; at least one moisture diverter configured to direct moisture away from the gripping module; and a sensing rod extending below a bottom surface of the gripping module, the sensing rod being coupled to a detector to determine contact between the sensing rod and the mounting surface.",
    "9. The device of claim 8, further comprising a controller configured to control engagement of the gripping module with the mounting surface based on a position of the sensing rod.",
    "10. The device of claim 9, wherein the controller is further configured to detect a frost buildup based on the position of the sensing rod.",
    "11. A device for engaging with a sample rack, comprising: a bracket configured to be coupled with an automated retrieval system; a gripping module configured to engage with a mounting surface of the sample rack; a shaft extending between the bracket and the gripping module; at least one moisture diverter configured to direct moisture away from the gripping module; and at least one locating pin extending from the bottom surface of the gripping module, the at least one locating pin being adapted to enter at least one hole in the mounting surface during engagement of the gripping module with the mounting surface.",
    "12. A method of engaging with a sample rack, comprising: lowering a gripping module toward a mounting surface of the sample rack until a spacer of the gripping module contacts the mounting surface, a bottom surface of the gripping module being isolated from the mounting surface; detecting contact between a sensing rod and the mounting surface, the sensing rod extending below the gripping module; engaging the gripping module to latch with the mounting surface; and raising the gripping module with the sample rack.",
    "13. The method of claim 12, wherein the spacer includes a spacer pin.",
    "14. The method of claim 12, further comprising directing moisture away from the gripping module via at least one moisture diverter.",
    "15. The method of claim 14, wherein the moisture includes liquid moisture.",
    "16. The method of claim 12, further comprising controlling engagement of the gripping module with the mounting surface based on a position of the sensing rod.",
    "17. The method of claim 12, further comprising detecting a frost buildup based on a position of the sensing rod.",
    "18. The method of claim 12, further comprising aligning the gripping module and the mounting surface via at least one locating pin extending below the bottom surface of the gripping module.",
    "19. The method of claim 12, further comprising elevating the sample rack into an insulated sleeve.",
    "20. The method of claim 12, further comprising elevating the sample rack to a position aligning a selected sample box of the sample rack to a port.",
    "21. A method of engaging with a sample rack, comprising: lowering a gripping module toward a mounting surface of a sample rack until a spacer of the gripping module contacts the mounting surface, a bottom surface of the gripping module being isolated from the mounting surface; detecting contact between a sensing rod and the mounting surface, the sensing rod extending below the gripping module; engaging the gripping module to latch with the mounting surface; raising the gripping module with the sample rack; and directing moisture away from the gripping module via at least one moisture diverter; wherein the at least one moisture diverter includes a drip shield including angled leaves configured to direct moisture away from the bottom surface of the gripping module."
  ],
  "description_excerpt": "Cryopreservation is a process essential to maintaining the integrity of biological substances over extended periods of storage. At sufficiently low temperatures, all chemical processes and biological functions of such substances are effectively halted, allowing them to be stored safely over nearly any length of time. A cryogenic storage freezer enables such storage by providing an insulated and controlled cryogenic environment to accommodate a number of biological or other samples. In typical storage freezers, samples are loaded into racks or trays, each of which hold several samples. The racks or trays are manually removed from the cryogenic environment of the freezer, presenting the rack or tray to a user for removing samples from, or adding samples to, the storage freezer.\n\nExample embodiments of the disclosure provide a cryogenic storage system comprising a freezer and an automated retrieval system. The freezer stores a plurality of sample racks in a cryogenic environment, and includes a door enabling access to the cryogenic environment through a port at the top portion of the freezer. The retrieval system may include a drive system, an insulating sleeve and a rack puller. The drive system may be mounted to the top portion of the freezer, and operates to rotate the sample racks to align a selected one of the sample racks with the port. The insulating sleeve houses the selected sample rack above the port, and includes a sleeve port for enabling a user to access a selected sample box from the sample rack.",
  "cpc": [
    "B65G 1/045",
    "A01N 1/145",
    "B65G 1/0464",
    "B65G 1/06",
    "B65G 1/10",
    "F25D 15/00",
    "F25D 21/02",
    "F25D 21/04",
    "F25D 2400/38",
    "F25D 25/02",
    "F25D 25/04",
    "F25D 29/001",
    "F25D 29/005",
    "F25D 3/105",
    "F25D 3/11"
  ],
  "ipc": [
    "B65G 1/04",
    "B65G 1/06",
    "B65G 1/10",
    "F25D 21/02",
    "F25D 21/04",
    "F25D 25/02",
    "F25D 25/04",
    "F25D 29/00",
    "F25D 3/10",
    "F25D 3/11"
  ],
  "assignees": [
    "Brooks Automation Inc"
  ],
  "inventors": [
    "Robert T. Caveney",
    "Frank Hunt",
    "Lingchen Sun",
    "Julian D. Warhurst",
    "Bruce S. Zandi",
    "Anthony C. Bonora"
  ],
  "filing_date": "2019-05-24",
  "publication_date": "2020-05-26",
  "grant_date": "2020-05-26",
  "priority_date": "2015-03-30",
  "application_number": "US-201916422507-A",
  "family_id": "55702158",
  "cited_by_count": 3,
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}