Ectrodactyly

{
  "id": "MLC-T-CHM-003566",
  "term": "Ectrodactyly",
  "field": "Chemistry",
  "definition": "A congenital limb malformation in which one or more of the middle fingers or toes are missing, leaving a cleft down the centre of the hand or foot, the pattern called split-hand/split-foot or lobster-claw deformity. It occurs on its own or as one feature of a genetic syndrome, and severity runs from a shallow cleft to loss of every digit except the outermost ones. EEC syndrome (ectrodactyly, ectodermal dysplasia and cleft lip or palate) is a well-known syndromic form caused by mutations in the TP63 gene.",
  "synonyms": [
    "cleft hand",
    "lobster-claw deformity",
    "split hand"
  ],
  "subject": "Chemistry and Human Health",
  "see_also": [
    "congenital"
  ],
  "references": [
    "PAC, 2016, 88, 713. 'Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)' on page 747 (https://doi.org/10.1515/pac-2015-1202)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/ectrodactyly/"
}