Nucleosome

{
  "id": "MLC-T-ENV-019195",
  "term": "Nucleosome",
  "field": "Environment",
  "definition": "1. A nucleosome is the basic repeating unit of eukaryotic chromatin. In a human cell, about six feet of DNA must be packaged into a nucleus with a diameter less than a human hair. A single nucleosome consists of about 150 base pairs of DNA sequence wrapped around a core of histone proteins. The nucleosomes are arranged like beads on a string. They are repeatedly folded in on themselves to form a chromosome.\n\n2. Any of the repeating globular subunits of chromatin that consist of a complex of DNA and histone and are thought to be present only during interphase.\n\n3. The repeating structural units of chromatin, each consisting of approximately 200 base pairs of DNA wound around a protein core. This core is composed of the histones H2A, H2B, H3, and H4.",
  "subject": "Biological substances",
  "references": [
    "NIH Genetics Home Reference Glossary"
  ],
  "url": "https://mlchart.com/terminology/environment/nucleosome/"
}