anti-CD19 cord blood-derived CAR-NK cells

{
  "id": "MLC-T-ONC-010254",
  "term": "anti-CD19 cord blood-derived CAR-NK cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of cord blood (CB)-derived natural killer (NK) cells that have been genetically modified and transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) cluster of differentiation 19 (CD19), with potential immunomodulating and antineoplastic activities. Upon administration, the anti-CD19 CB-derived CAR-NK cells recognize, bind to and induce selective cytotoxicity in CD19-expressing tumor cells. CD19 is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies.",
  "synonyms": [
    "CB anti-CD19 CAR NK Cells NK019",
    "CAR-NK019",
    "CB CAR-NK019",
    "CB CAR NK cells NK019"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd19-cord-blood-derived-car-nk-cells/"
}