anti-CD20 bispecific antibody DR-0201

{
  "id": "MLC-T-ONC-010287",
  "term": "anti-CD20 bispecific antibody DR-0201",
  "field": "Oncology and biomedicine",
  "definition": "A bispecific monoclonal antibody that targets the human tumor-associated antigen (TAA) CD20, with potential immunomodulating and antineoplastic activities. Upon administration, anti-CD20 bispecific antibody DR-0201 targets and binds to CD20 on B-cell surface. This results in CD20-mediated signaling blockade and may induce phagocytosis of CD20-overexpressing cells by tissue-resident and trafficking myeloid cells, such as macrophages. This results in a depletion of pathogenic B cells. CD20 is overexpressed by certain cancer cell types and in various autoimmune diseases.",
  "synonyms": [
    "bispecific myeloid cell engager DR-0201",
    "MCE DR-0201"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd20-bispecific-antibody-dr-0201/"
}